Is adult neurogenesis essential for olfaction?
نویسندگان
چکیده
منابع مشابه
Cdk5 is essential for adult hippocampal neurogenesis.
The molecular factors regulating adult neurogenesis must be understood to harness the therapeutic potential of neuronal stem cells. Although cyclin-dependent kinase 5 (Cdk5) plays a critical role in embryonic corticogenesis, its function in adult neurogenesis is unknown. Here, we assessed the role of Cdk5 in the generation of dentate gyrus (DG) granule cell neurons in adult mice. Cre recombinas...
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Constitutive neurogenesis clearly occurs within the adult central nervous system of almost all mammals. This process generates new neurons in at least two areas of the brain: the olfactory bulb (OB) and the dentate gyrus (DG) of the hippocampus. However, it remains unknown why new neurons specifi cally populate those two neural structures rather than other areas. In empirical experiments, adult...
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In the mid-sixties a novel discovery faced the traditional idea on the immutability of the adult brain. Up to then, scientist assumed that once the brain has reached its maturity neurons can die, but nor regenerate—e.g., " Once the development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. In the adult centers, the nerve paths are something fix...
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Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
متن کاملAdult Hippocampal Neurogenesis and Memory
Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2011
ISSN: 0166-2236
DOI: 10.1016/j.tins.2010.09.006